Endocrine Abstracts

Bisphosphonates are the mainstay of treatment for metabolic bone diseases such as post-menopausal osteoporosis and Paget’s disease. Enormous progress has been made over the last few years in understanding how these drugs act at the molecular level. After targeting bone and selective internalisation by osteoclasts, simple bisphosphonates are incorporated into cytotoxic, non-hydrolysable analogues of ATP. By contrast, the more potent nitrogen-containing bisphosphonates inhi...